New Cochrane evidence on Ritalin for ADHD

Posted on January 7, 2016

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A new Cochrane Systematic Review highlighted the need for caution when prescribing Methylphenidate (also known as Ritalin®, Concerta®, Medikinet®, and Equasym®) for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents.

The review included data from 185 randomized controlled trials involving more than 12,000 children or adolescents where researchers found that methylphenidate led to modest improvements in ADHD symptoms, general behaviour, and quality of life. Additionally it showed that children were more likely to experience sleep problems and loss of appetite while taking methylphenidate. However, the researchers’ confidence in all results was very low due to the possible low quality of the data they investigated. That is possibly due to inclusion of trials that may not have had appropriate blinding of the people involved in the trials to which treatment the children were taking. In addition, the reporting of results was not complete in many of the trials, and for some analyses there was variation among trial results.

The Cochrane Review was met with plenty of media coverage. Many articles jumped to the conclusion that Methylphenidate may not help ADHD despite the authors of the study urging that clinicians and families should not rush to discontinue using methylphenidate if a child or young person has experienced benefits without experiencing adverse effects.

However, the fact that this review deemed a lot of the evidence related to the treatment of ADHD with methylphenidate as low quality is very interesting given the following points:

All the above makes it quite absurd to know that there aren’t large scale, well-conducted clinical trials available to inform us of the efficacy of drugs like methylphenidate that are costing billions of dollars globally. It also reminds us of the importance of evidence-based medicine and the necessity to systematically assess all treatments for all disorders to ensure benefit and avoid harm for all patients.

Nevertheless, until such trials are available, clinicians and families must weigh the risks versus benefits of using methylphenidate for ADHD and ensure continuous monitoring for improvement or development of side effects.

Norah Essali

Norah Essali

Hi! I'm a medical student from Syria. I hope you find my posts useful!

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New Cochrane evidence on Ritalin for ADHD by Norah Essali is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. Unless otherwise stated, all images used within the blog are not available for reuse or republication as they are purchased for Students 4 Best Evidence from

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