Blinding is a common element used in rigorously designed trials. Most people are familiar with the general concept but what is its purpose and what is the best way to perform it? This blog by Neelam Khan explores both of these questions and discusses ways to tackle situations where blinding cannot be done.
In this blog, Julie Duncan Millar, PhD Student and Physiotherapist, reflects on the difficulties of comparing and sharing upper limb rehabilitation trial data and proposes a condensed toolkit of measures recommended for researchers to use in future trials.
Canada is in the midst of an opioid crisis and prescriptions have something to do with it. The question is, what? Lauren Gorfinkel discusses the need for new research which adequately investigates the ways in which prescription opioids enter and influence the lives of not only those who are prescribed opioids, but those that are not.
Saul Crandon provides an overview of Case-control and Cohort studies: what are they, how are they different, and what are the pros and cons you need to consider in each study design.
In this blog, Leonardo provides 5 interpretations that you should consider when you read or hear about a reported association in observational studies.
Is evidence-based medicine a fairy tale? With this in mind, Foo Wee brings her personal experience into a review of the evidence available for analgesic treatment of G6PD deficient children. This blog won 2nd prize in the recent Cochrane Malaysia blog writing competition.
This blog provides a detailed overview of the Delphi Technique, a method of congregating expert opinion through a series of iterative questionnaires, with a goal of coming to a group consensus. It covers what it is, the process involved, pros and cons and when you would consider using it.
Tarang Sharma was lead-author of a recent article entitled “The Yusuf-Peto method was not a robust method for meta-analyses of rare events data from antidepressant trials”. In this blog, Tarang gives more details about meta-analysis methods of rare events and sparse data, and why these can lead to misleading results.
This blog provides an introduction to sample size and power; what it is, why it’s important to consider when designing a study, and how to carry out a power calculation.
A pilot study is a small scale preliminary study conducted in order to evaluate feasibility of the key steps in a future, full-scale project. Pilot studies can teach researchers about any amendments they will need to make to the design of the future study, in order to minimise waste of time and resources.
This blog provides a detailed overview of the concept of ‘blinding’ in randomised controlled trials (RCTs). It covers what blinding is, common methods of blinding, why blinding is important, and what researchers might do when blinding is not possible. It also explains the concept of allocation concealment.
This is the story of the MedLit Blitz birthday celebration. Cochrane Crowd joined forces with another innovative platform Mark2Cure to run the MedLit Blitz, consisting of three events: a webinar, a 24 hour Cochrane Crowd screening challenge, and a 24 hour Mark2Cure challenge.
Join Cochrane Crowd, their partner Mark2Cure and their collective global volunteer network for an online MedLit Blitz, May 9th-12th.
This blog takes a critical look at the use of functional electronic stimulation for children with cerebral palsy.
This blog discusses the problem of confirmation bias: our tendency to favour answers that confirm ideas and beliefs that we already have. It also discusses two possible solutions to this problem: 1) referring to systematic reviews, which take account of ALL the available evidence and 2) actively seeking out information which may challenge our preconceptions.