Non-invasive ventilation after acute respiratory failure

Posted on June 1, 2017

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This blog is a critical appraisal of the following randomized controlled trial: Noninvasive ventilation immediately after extubation improves weaning outcome after acute respiratory failure. 


Mechanical ventilation is an essential requirement for 44.5 percent of patients admitted to critical care units in the UK (excluding Scotland), per 2012 statistics (Harrison 2014). Prolonged dependence on mechanical ventilation can result in secondary complications. Therefore, it’s recommended that weaning (gradual reduction of ventilatory support) should be implemented as soon as possible (Pettit 2014). The following study focuses on weaning from invasive mechanical ventilation. Unsuccessful extubation often occurs in intensive care units (ICU) and is associated with increased hospital length of stay, morbidity and mortality (Kulkarni and Agarwal 2008).

Current research has used non-invasive ventilation (NIV) to successfully wean patients from invasive ventilation and significantly reduce the rate of reintubation and mortality compared to standard weaning (Burns et al. 2013). Chronic obstructive pulmonary disease patients have mainly been the focus of research.

The study

The trial was carried out over 12 months in the adult general ICU of a university hospital. The primary objective of this trial was to compare the effect of the use of NIV immediately after extubation to an oxygen mask (OM) in preventing reintubation. ICU length of stay and hospital mortality were the secondary objectives. 40 patients met the inclusion criteria (acute respiratory failure; invasive mechanical ventilation (>72hrs); no contraindications to NIV). 20 patients were randomised into each group before extubation. The intervention group received NIV through a nasal mask immediately after extubation for 24hours. After 24 hours, a nebulization oxygen mask replaced the NIV. Oxygen was supplied through the nasal mask to all patients in this group. The control group received oxygen through a facial mask immediately after extubation. 38 patients finished the trial (2 withdrew from the OM group).

Results of the study

There was a statistically significant difference in the rate of reintubation (5% NIV, 39% OM) and hospital mortality (0% NIV, 22.2% OM) between groups. There was no statistically significant difference in ICU length of stay between groups.

Critique of the study

The critique of this study will be guided by the CASP checklist for randomized controlled trials (CASP 2013).


This study concluded that using NIV immediately after extubation from invasive mechanical ventilation was more successful than an oxygen mask in a mixed ICU population. The results showed significant reductions in the rate of reintubation and hospital mortality but no significant difference in ICU length of stay.

Caution however must be taken when interpreting these findings. The small sample size, and the uncertainty of the extent of the clinical effect suggests the need for further research.


BURNS, K. E. A., MEADE, M. O., PREMJI, A. and ADHIKARI, N. K. J., 2013. Noninvasive ventilation as a weaning strategy for mechanical ventilation in adults with respiratory failure: A Cochrane systematic review. Canadian Medical Association Journal [online]. December, vol. 186, no. 3, pp. 112–122. [viewed 5 January 2017]. Available from:

CRITICAL APPRAISAL SKILLS PROGRAMME (CASP)., 2013. Randomised Controlled Trials Checklist [online]. [viewed 19 December 2016]. Available from:

HARRISON, D., 2014. Number of mechanically ventilated patients during 2012 [online]. London: ICNARC. [viewed 4 January 2017].

IRWIG, L., IRWIG, J., TREVENA, L. and SWEET, M., 2008. Relative risk, relative and absolute risk reduction, number needed to treat and confidence intervals [online]. London: Hammersmith Press [viewed 5 January 2017]. Available from:

KULKARNI, A. and AGARWAL, V., 2008. Extubation failure in intensive care unit: Predictors and management. Indian Journal of Critical Care Medicine [online]. vol. 12, no. 1, p. 1-9. [viewed 4 January 2017]. Available from:

ORNICO, S. R., LOBO, S. M., SANCHES, H. S., DEBERALDINI, M., TÓFOLI, L. T., VIDAL, A. M., SCHETTINO, G. P., AMATO, M. B., CARVALHO, C. R. and BARBAS, C. S., 2013. Noninvasive ventilation immediately after extubation improves weaning outcome after acute respiratory failure: A randomized controlled trial. Critical Care [online]. vol. 17, no. 2. [viewed 18 December 2016] Available from:

PETTIT, R., 2014. Guideline for weaning an adult patient from invasive ventilation [online]. 2nd ed. p.2. [viewed 4 January 2017].

Grainne McGoldrick

3rd year physiotherapy student at QMU. I play the violin in my spare time and enjoying going to see traditional Irish bands.

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Non-invasive ventilation after acute respiratory failure by Grainne McGoldrick is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. Unless otherwise stated, all images used within the blog are not available for reuse or republication as they are purchased for Students 4 Best Evidence from

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