This blog provides a detailed overview of the concept of ‘blinding’ in randomised controlled trials (RCTs). It covers what blinding is, common methods of blinding, why blinding is important, and what researchers might do when blinding is not possible. It also explains the concept of allocation concealment.
This blog provides a basic overview of: 1) what a meta-analysis is; 2) why they’re considered the ‘gold standard’ of evidence; and 3) how a meta-analysis is carried out.
This blog explains what allocation concealment is & why it’s important, in terms of preventing researchers from (intentionally or otherwise) influencing which participants are assigned to a given intervention group.
Outcome switching is a major problem in clinical trial reporting that distorts the evidence doctors and patients use to make real-world clinical decisions. Numerous prevalence studies have already shown this to be an extremely common problem, even in top medical journals. However the CEBM Outcome Monitoring Project (COMPare) has taken a new approach: writing to journals to correct the record on individual trials, in the hope that individual accountability and open data sharing will help solve this important problem. Our main question was: how will the journals respond? This blog tells the story of COMPare so far.
Patients, carers and members of the public offer a unique perspective in health and social care research, adding to the expertise of the research team. Improving healthcare services will only be possible by involving the people accessing those services.
Currently decisions made on treatment of bronchiectasis are based on guidelines which have a very poor evidence base. Read more to find out!
A description of the two types of data analysis – “As Treated” and “Intention to Treat” – using a hypothetical trial as an example
Randomised Controlled Trials (RCTs) are central to evidence-based healthcare; but they themselves are riddled with inefficiency. Trial Forge aims to change that.
Sense About Science explains how scientists cope with uncertainty and unknowns in research, whether or not that matters, and how we can practically use scientific results in spite of not always knowing everything.
YouTube video series by Dr. Aaron Carroll called Healthcare Triage, where his motto is, “To the Research!”
In his book, A Scientist in Wonderland, Edzard Ernst describes his life and career. He becomes a pioneer in researching alternative medicine, and as one would expect, makes plenty of enemies along the way.
The Cochrane Dementia Group’s Modifiable Risk Factors project has utilized new crowdsourcing techniques to speed up the review process. Sofía Jaramillo takes a look behind the scenes.
Danny Minkow looks into how the COMET initative is working to developing and apply an agreed-upon set of outcomes measures in medical research. Why is it needed?
From Richard’s Reviews, we highlight the importance of constantly rethinking how we manage patients with kidney stones (nephorlithiasis) and heart attacks (myocardial infarctions).
From Richard’s review this week, we look at whether bisphosphonates can prevent breast cancer, and whether bivalirudin is actually any better than good old-fashioned heparin in patients with ACS undergoing percutaneous coronary intervention