This blog explains what allocation concealment is & why it’s important, in terms of preventing researchers from (intentionally or otherwise) influencing which participants are assigned to a given intervention group.
Outcome switching is a major problem in clinical trial reporting that distorts the evidence doctors and patients use to make real-world clinical decisions. Numerous prevalence studies have already shown this to be an extremely common problem, even in top medical journals. However the CEBM Outcome Monitoring Project (COMPare) has taken a new approach: writing to journals to correct the record on individual trials, in the hope that individual accountability and open data sharing will help solve this important problem. Our main question was: how will the journals respond? This blog tells the story of COMPare so far.
A brief overview of the concept of bias and what it means. This blog also describes 2 particular types of bias that are perhaps less well known to students.
Katherine Stagg explores the impact of language bias and how the language of publications can affect our evidence base.
Deevia takes a look at ‘effect modification’ and ‘confounding’ and explains the differences.
In his book, A Scientist in Wonderland, Edzard Ernst describes his life and career. He becomes a pioneer in researching alternative medicine, and as one would expect, makes plenty of enemies along the way.
Does industry sponsorship of research inevitably lead to bias? And does this bias extend to government advice and policy?
In his new book, Dr. Goldacre continues his crusade of exposing quacks and pseudoscience, with an emphasis on how journalists totally mislead the public about what a scientific paper really says. He also chronicles his AllTrials quest by railing against the lack of transparency in clinical trials and publication bias.
In Richard’s Reviews this week, we look at progress in sharing clinical trial data through the All Trials campaign, and the nature of patient-centred outcomes research.
Publication bias is generally ascribed to failure by researchers to submit studies for publication. This current study aims to further evaluate whether the editorial and peer review process also contributes to publication bias.
Key message: Evidence Based Medicine is useful for informing healthcare professionals what works, what doesn’t, and helping to determine if the benefits outweigh the harms, but it’s far from perfect. There are valuable lessons learned about research that we can share across disciplines. What is the Evidence Based Medicine problem? In 2005, Dr. John Ioannidis, a […]
The Systematic Review is the highest level of research design and brings available evidence to find an answer to a research question. Read Danny’s blog.
In search of a book with simple, comprehensible definitions and examples of clinical evidence? Do you want to take the first step in understanding common terms in clinical evidence as well as commonly used methods and their pitfalls? This review will inform you if this is the book you’re looking for.
Danny takes us on a tour of the Evidence-Based Medicine Pyramid and the wonders within.