This blog discusses the issue of statistical significance (whether a difference, such as an improvement in symptoms, is unlikely to have occurred by chance) vs. clinical significance (whether a difference, such as an improvement in symptoms, is meaningful and patient to patients).
This blog discusses the problem of confirmation bias: our tendency to favour answers that confirm ideas and beliefs that we already have. It also discusses two possible solutions to this problem: 1) referring to systematic reviews, which take account of ALL the available evidence and 2) actively seeking out information which may challenge our preconceptions.
In 2016, the World Health Organization published a new handbook on the classification of tumours of the brain and spinal cord. This blog takes a look at some of the changes in the way we classify tumours, given advancements in molecular testing.
This blog takes a critical look at a study investigating whether more intense therapy following a neurological event (e.g. a stroke or traumatic brain injury) can lead to a reduction in length of stay in a rehabilitation unit.
This blog provides a basic overview of: 1) what a meta-analysis is; 2) why they’re considered the ‘gold standard’ of evidence; and 3) how a meta-analysis is carried out.
In the fourth blog of our new series, Understanding Evidence, the Cochrane UK Trainees introduce their group and invite you to get involved. Join in the conversation on Twitter @CochraneUK #CochraneTrainees #understandingevidence.
In the second blog of our new series Understanding Evidence, Iain Chalmers, the founding director of Cochrane UK, looks at developments in research on prenatal corticosteroids since the work which gave rise to the Cochrane logo. Join in the conversation on Twitter @iainchalmersTTi @CochraneUK #understandingevidence
This blog explains what allocation concealment is & why it’s important, in terms of preventing researchers from (intentionally or otherwise) influencing which participants are assigned to a given intervention group.
In this blog, 15 year old Liv, who hopes to be a dental health professional, writes about new Cochrane evidence on whether fluoride mouthrinses can prevent tooth decay in children.
Let’s find out why physicians sometimes contradict each other from a statistical perspective. And see how students can learn from that.
Let’s figure out how the epidemiologists determine the diagnostic thresholds by studying the cases of anemia and type II diabetes.
Come with me. I’ll show you the best way to display the efficacy of a drug. And the pitfalls around it. Ladies and gentlemen, welcome to the world of Number needed to treat.
When dealing with a difficult question, we tend to seek the answer for a simpler one, that seems to be relevant. However, a seductive trap awaits us here. Come with me, I’ll show you the world of surrogate endpoints.
Here we will address the problem with cancer screening interventions regarding the potential benefits and harms of these strategies.
Managing hypertension is complex, involves lifestyle modifications such as physical activity and dietary interventions, as well as drugs. Here, we highlight the evidence from Cochrane about which drug is better as a first-line therapy.