Beware of conflicting interests

Posted on July 10, 2017

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This is the seventh in a series of 34 blogs based on a list of ‘Key Concepts’. Each blog will explain one Key Concept that we need to understand to be able to assess treatment claims. 

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Conflicting interests are a pretty inflammatory issue in the field of healthcare. It’s easy to be too naive, too nihilistic, or just confused about this problem. So what are conflicting interests and why are they a problem?

Where’s the danger, exactly?

Conflicting interests are “circumstances that create a risk that professional judgments or actions regarding a primary interest will be unduly influenced by a secondary interest”. The primary interest for us – as (future) healthcare professionals – is to make the best treatment decisions. This requires us to take account of: 1) the best available research evidence; 2) our patients’ preferences; 3) our clinical judgement. Being ‘disinterested’ (i.e. not being influenced by considerations of personal advantage) is the hallmark of good research and practice.

However any number of factors could affect a researcher or clinician’s judgement and make it difficult for them to remain impartial. For example, income, rewards or gifts from pharmaceutical companies or sponsors of drugs and medical devices. Career prospects and power could also be sources of conflicting interests. Conflicting interests may not necessarily be tangible. They could arise from commitments, gratitude, respect, loyalty, ideologies, political or religious beliefs. Any of these can be problematic because they can bias the decisions researchers and clinicians make. This can harm patients.

Conflicting interests can lead to a distorted evidence base…

Conflicting interests can lead to sponsor and/or researcher bias. There is a myriad of ways to make conclusions misleading in one’s favour. This can range from out-and-out fraud to more subtle, subconscious biases. Indeed biased researchers may – intentionally or unintentionally – make use of other types of bias in pursuit of their vested interests. Among other types of bias, these may include: 1) design bias (where a study is designed in favour of the sponsor’s treatment); 2) analysis bias (where the methods of analysis are chosen in favour of the sponsor’s treatment); 3) and/or reporting bias (where a researcher might ‘spin’ the results of a study to overstate the benefits of a treatment and/or understate the potential harms).

Biased sponsors or researchers may also choose not to publish their study if it does not paint their own results for a particular treatment in a favourable light. Given that there is often considerable uncertainty about which is the most favourable treatment anyway, conflicting interests only add to the confusion.

A Finnish medical student’s confessions…

I’ve had a few nice dinners and breakfasts paid for by a pharmaceutical company in medical school. Now, I do not attend any of these. I think it’s just unnecessary and terrible practice.

The accompanying lectures were about the company and some of their products. One representative encouraged us to buy shares in the company. A big selling point was that the company is Finnish; they were trying to tap into our patriotism. So the representative not only tried to create a financial relationship via stocks and shares, but she also tried to convince us that the country in which a treatment is produced should somehow matter to us. Just another conflicting interest.

At the time, the food and free samples didn’t feel so wrong. But patients are ultimately paying for this.

The most critical thing I heard about this routine practice was from a clinical teacher who warned us that “there are no free meals”. But people think: how does all of this cause any unacceptable harm?

Well, what my clinical teacher implied is this: by attending such events, you allow marketing professionals with obvious interests to spin your emotions and memories when your interest should be only that of patients. The aim of such events is simple: to make us think favourably about a company’s product(s). But we should really favour their product only if it has been demonstrated to be a favourable product in fair, systematic reviews of the evidence!

Looking at the bigger picture, the pharmaceutical industry carries out marketing in various other forms as well. Moreover, companies are frequently fined for marketing in illegal manners.

What’s the evidence?

So how do we know that conflicting interests distort the evidence base and influence decision-making, and what’s the likely impact? In short, the evidence tells us that:

I could go on, with numerous other studies indicating that conflicting interests can distort the evidence base and affect healthcare decision-making. Ultimately, we should all be careful not to be misled by claims made by those with conflicting interests.

References

Click here for learning resources which further explain and illustrate Key Concept 1.7. Beware of conflicting interests

Read the rest of the blogs in the series here

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Eero Teppo

Eero Teppo

Hey! I'm a medical student from Finland who is trying to figure out what it means to practice rational medicine. I'm really excited about what we could achieve soon by sticking together evidence-based medicine and artificial intelligence in healthcare. I pour everything at least remotely healthcare-related I consider interesting into my Twitter feed.

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Beware of conflicting interests by Eero Teppo is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. Unless otherwise stated, all images used within the blog are not available for reuse or republication as they are purchased for Students 4 Best Evidence from shutterstock.com.

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